| Date | Opponent | Location | Time/Result | |  | | Aug. 20, 2010 | @ USC Upstate | Spartanburg, S.C. | 3-0 W | Recap | Box | | Aug. 23, 2010 | College of Charleston (Silver Cup Match) | Charleston, S.C. (Blackbaud Stadium) | 2-3 L | Recap | Box | | Aug. 27, 2010 | University of Maine | Charleston, S.C. | 2-1 W | Recap | Box | | Aug. 29, 2010 | Jacksonville | Charleston, S.C. | 3-2 W | Recap | Box | | Sep. 5, 2010 | @ Georgia Southern | Statesboro, Ga. | 2-3 L | Recap | Box | | Sep. 10, 2010 | @ U.S. Naval Academy (Navy Tournament) | Annapolis, Md. | 7 p.m. | Recap | Box | | Sep. 12, 2010 | vs. Towson (Navy Tournament) | Annapolis, Md. | noon | Recap | Box | | Sep. 18, 2010 | The Citadel  | Charleston, S.C. | 11 a.m. | Recap | Box | | Sep. 21, 2010 | South Carolina State  | Charleston, S.C. | 4 p.m. | Recap | Box | | Sep. 28, 2010 | Longwood | Charleston, S.C. | 3 p.m. | Recap | Box | | Oct. 2, 2010 | Liberty * | Charleston, S.C. | 3 p.m. | Recap | Box | | Oct. 4, 2010 | High Point * | Charleston, S.C. | 4 p.m. | Recap | Box | | Oct. 8, 2010 | @ Radford * | Radford, Va. | 7 p.m. | Recap | Box | | Oct. 10, 2010 | @ Virginia Military Institute* | Lexington, Va. | 1 p.m. | Recap | Box | | Oct. 16, 2010 | Asheville* | Charleston, S.C. | 11 a.m. | Recap | Box | | Oct. 18, 2010 | Presbyterian College* | Charleston, S.C. | 4 p.m. | Recap | Box | | Oct. 22, 2010 | Coastal Carolina (Blackbaud Stadium)* | Charleston, S.C. | 7 p.m. | Recap | Box | | Oct. 27, 2010 | @ Winthrop * | Rock Hill, S.C. | 7 p.m. | Recap | Box | | Oct. 29, 2010 | @ Gardner-Webb * | Boiling Springs, N.C. | 6 p.m. | Recap | Box | | Nov. 4-7, 2010 | Big South Tournament | Radford, Va. | | Recap | Box |
| | Record: 3-2 (0-0 BSC) Home events are in bold.
* - indicates Big South Conference event
All times are Eastern. |
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