| Date | Opponent | Location | Time/Result |
| Feb. 15, 2013 | Eastern Kentucky | Charleston, S.C. | 17-4 W |
| Feb. 16, 2013 | Eastern Kentucky | Charleston, S.C. | 1-5 L |
| Feb. 17, 2013 | Eastern Kentucky | Charleston, S.C. | (7 inn.) 6-5 W |
| Feb. 19, 2013 | @ College of Charleston | Charleston, S.C. | 5-13 L |
| Feb. 20, 2013 | UNC Wilmington | Charleston, S.C. | 7-6 W |
| Feb. 24, 2013 | Marist | Charleston, S.C. | (7 inn.) 9-0 W |
| Feb. 24, 2013 | Marist | Charleston, S.C. | (7 inn.) 1-2 L |
| Feb. 27, 2013 | The Citadel | Charleston, S.C. | 8-6 W |
| Mar. 1, 2013 | @ North Florida | Jacksonville, Fla. | 5-10 L |
| Mar. 2, 2013 | vs. Jacksonville State | Jacksonville, Fla. | 4-7 L |
| Mar. 3, 2013 | @ North Florida | Jacksonville, Fla. | 1-9 L |
| Mar. 5, 2013 | Savannah State | Charleston, S.C. | 8-4 W |
| Mar. 6, 2013 | College of Charleston | Charleston, S.C. | 1-15 L |
| Mar. 9, 2013 | Siena | Charleston, S.C. | 8-7 W |
| Mar. 9, 2013 | Siena | Charleston, S.C. | 5-10 L |
| Mar. 10, 2013 | Siena | Charleston, S.C. | 8-3 W |
| Mar. 12, 2013 | Ohio State | Charleston, S.C. | 3-6 L |
| Mar. 13, 2013 | @ Clemson | Clemson, S.C. | 1-3 L |
| Mar. 15, 2013 | @ Liberty* | Lynchburg, Va. | 2-8 L |
| Mar. 16, 2013 | @ Liberty* | Lynchburg, Va. | 4-8 L |
| Mar. 17, 2013 | @ Liberty* | Lynchburg, Va. | 1-3 L |
| Mar. 20, 2013 | @ UNC Wilmington | Wilmington, N.C. | 3-10 L |
| Mar. 22, 2013 | @ The Citadel | Charleston, S.C. | 4-6 L |
| Mar. 26, 2013 | @ Old Dominion | Norfolk, Va. | 3-4 L |
| Mar. 29, 2013 | UNC Asheville* | Charleston, S.C. | 6-2 W |
| Mar. 30, 2013 | UNC Asheville * | Charleston, S.C. | 11-7 W |
| Mar. 30, 2013 | UNC Asheville* | Charleston, S.C. | 8-1 W |
| Apr. 2, 2013 | @ South Carolina | Columbia, S.C. | 5-9 L |
| Apr. 5, 2013 | @ Gardner-Webb* | Boiling Springs, N.C. | 4-7 L |
| Apr. 6, 2013 | @ Gardner-Webb* | Boiling Springs, N.C. | 2-4 L |
| Apr. 7, 2013 | @ Gardner-Webb* | Boiling Springs, N.C. | 2-3 L |
| Apr. 9, 2013 | Georgia Southern | Charleston, S.C. | 2-3 L |
| Apr. 10, 2013 | @ USC-Upstate | Spartanburg, S.C. | 9-3 W |
| Apr. 13, 2013 | VMI* | Charleston, S.C. | (10 inn.) 2-4 L |
| Apr. 13, 2013 | VMI* | Charleston, S.C. | 6-4 W |
| Apr. 14, 2013 | VMI* | Charleston, S.C. | 7-4 W |
| Apr. 17, 2013 | @ Savannah State | Savannah, Ga. | 11-5 W |
| Apr. 20, 2013 | Presbyterian* | Charleston, S.C. | 1-0 W |
| Apr. 20, 2013 | Presbyterian* | Charleston, S.C. | 4-8 L |
| Apr. 21, 2013 | Presbyterian* | Charleston, S.C. | 5-2 W |
| Apr. 23, 2013 | @ The Citadel | Charleston, S.C. | 5-8 L |
| May 1, 2013 | @ Georgia Southern | Statesboro, Ga. | 6-7 L |
| May 3, 2013 | @ Winthrop (ESPN3)* | Rock Hill, S.C. | 3-8 L |
| May 4, 2013 | @ Winthrop* | Rock Hill, S.C. | 6-3 W |
| May 4, 2013 | @ Winthrop* | Rock Hill, S.C. | 1-3 L |
| May 7, 2013 | Savannah State | Charleston, S.C. | 8-3 W |
| May 8, 2013 | USC Upstate | Charleston, S.C. | 7-8 L |
| May 11, 2013 | @ Radford* | Radford, Va. | 8-7 W |
| May 11, 2013 | @ Radford* | Radford, Va. | 3-8 L |
| May 12, 2013 | @ Radford* | Radford, Va. | 13-7 W |
| May 14, 2013 | The Citadel | Charleston, S.C. | 6-21 L |
| May 16, 2013 | Coastal Carolina* | Charleston, S.C. | 7-3 W |
| May 17, 2013 | Coastal Carolina* | Charleston, S.C. | 2-6 L |
| May 18, 2013 | Coastal Carolina* | Charleston, S.C. | 4-5 L |
| May 21-25, 2013 | No. 1 Campbell (Big South Tournament) | Lynchburg, Va. | 4:30 p.m. |
| May 22, 2013 | No. 4 Radford/No. 5 Liberty | Lynchburg, Va. | |
Record: 22-32 (11-13 BSC) Home events are in bold. |